The Upstream Lab is based in the Centre for Urban Health Solutions, in the Li Ka Shing Knowledge Institute at St. Michael’s Hospital in Toronto. The Upstream Lab was founded in 2016 and developed to create a space to advance thinking, research, education and collaboration around addressing the social determinants of health. As a program, it is dedicated to: incubating novel interventions that tackle social factors that impact on health, rigorous evaluation of interventions, sharing findings widely, and training “upstreamists” to become change agents.